Development and Validation of RP-HPLC Method for the Determination of Dexrabeprazole Sodium

A rapid and simple liquid chromatographic method was developed for the quantitative determination of dexrabeprazole sodium in tablet dosage form. The reverse-phase analysis carried out by using a C-18 column. acetonitrile-phosphate buffer mixture used as mobile phase. obtained retention time 4.33∓0.02 min. 50:50 (v:v) acetonitrile:phosphate buffer(pH 7) 1.0 mL/min. flow rate. Quantification analyte based on measuring peaks areas at 272 nm. analytical performance RP-HPLC validated with respect to accuracy, precision, linearity, stability, robustness. linearity range 77-143 mg/L correlation coefficient 0.9989. LOD LOQ values were 0.010 0.034 mg/L, respectively.